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Charles Squarey

This is a reproduction of a book published before 1923. This book may have occasional imperfections such as missing or blurred pages, poor pictures, errant marks, etc. that were either part of the original artifact, or were introduced by the scanning process. We believe this work is culturally important, and despite the imperfections, have elected to bring it back into print as part of our continuing commitment to the preservation of printed works worldwide. We appreciate your understanding of the imperfections in the preservation process, and hope you enjoy this valuable book.

Alex Avdeef

Profiling compounds for drug–like properties Of the hundreds of thousands of compounds synthesized each year, most have almost no chance of becoming drugs. This problem exists because most molecules lack eht drug–like poperties necessary to enable them to be effective in vivo. To address this issue, Alex Avdeef’s Absorption and Drug Development shows the reader how to examine a compound’s pharmaceutical properties, emphasizing oral absorption. This book explains the different physiochemical methods currently used to analyze drug candidates and how to interpret these methods. Topics discussed include: The physicochemical needs of pharmaceutical research and development The flux model in terms of solubility, permeability, and charge state (pH) Ionization constants Experimental methods of measuring partition coefficients, log P and log D Partition coefficients where the lipid phase is made of liposomes formed from vesicles of bilayers of...

I. Prigogine

Providing the chemical physics field with a forum for critical, authoritative evaluations in every area of the discipline, the latest volume of Advances in Chemical Physics continues to provide significant, up–to–date chapters written by internationally recognized researchers. This volume is essentially devoted to helping the reader obtain general information about a wide variety of topics in chemical physics. Advances in Chemical Physics, Volume 114 includes chapters addressing vibrational energy flow, discrete variable representations and their utilization, the unified theory of photochemical charge separation, and the association, dissociation, acceleration, and suppression of reactions by laser pulses.

Clive Randall

Advances in Electronic Ceramics: Ceramic Engineering and Science Proceedings, Volume 28, Is 8 explores advances in dielectric, piezoelectric and ferroelectric materials; electroceramic materials for sensors; thermoelectric materials for power conversion applications; and transparent conductive oxides.

Marek Trojanowicz

This first book to cover different injection techniques not only provides a comprehensive overview of methodologies and instrumentation, it also covers recent advances in flow method analysis, with an appendix listing additional databases, instrumentation and methods on the Internet. A definite must–have for every chemist working in this field.

Narottam P. Bansal

Papers from The American Ceramic Society’s 31 st International Conference on Advanced Ceramics and Composites, held in Daytona Beach, Florida, January 21–26, 2007.

?-Linolenic acid is an organic compound found in many common vegetable oils. Systematically, it is named all-cis- 9,12,15-octadecatrienoic acid. In physiological literature, it is given the name 18:3 (n?3). ?-Linolenic acid is a carboxylic acid with an 18-carbon chain and three cis double bonds. The first double bond is located at the third carbon from the n end. Thus, ?-linolenic acid is a polyunsaturated n?3 (omega-3) fatty acid. It is an isomer of ?-linolenic acid, a polyunsaturated n?6 (omega-6) fatty acid.

James S. Fritz

New trends in solid–phase extraction for analytical use––a practical introduction. Owing to its low cost, ease of use, and nonpolluting means of preparing samples for analysis, solid–phase extraction (SPE) is fast overtaking traditional liquid––liquid methods in clinical, pharmaceutical, agricultural, and industrial applications. This book describes what analytical scientists and technicians need to know about this emerging procedure: how it works, how to choose from available techniques, how to utilize it effectively in the laboratory. Along with the historical perspective and fundamental principles, this practical book reviews the latest literature on solid–phase materials, equipment, and applications––including EPA–endorsed techniques. Special features include: ? Coverage of separation and uptake methods. ? Promising developments in the use of membrane disks. ? The advantages of using polymeric resins over silica materials. ? Mechanism and use of...

Ernest E. Ludwig

Applied Process Design for Chemical and Petrochemical Plants: Volume 3

Jorge Ancheyta, Fernando Trejo, Mohan Singh Rana

During the upgrading of heavy petroleum, asphaltene is the most problematic impurity since it is the main cause of catalyst deactivation and sediments formation. Exploring many aspects related to asphaltenes composition and conversion, Asphaltenes: Chemical Transformation during Hydroprocessing of Heavy Oils highlights the various changes that these heavy and complex molecules undergo during catalytic hydroprocessing. After defining and characterizing asphaltene structure, the book examines the composition of petroleum and the processes and catalysts for upgrading heavy oils. It then details the characterization of asphaltenes after hydroprocessing and the effect of reaction conditions on their structures. The authors also analyze the deactivation and characterization of spent hydroprocessing catalysts as well as the role played by asphaltenes. They cover sediments formation during hydroprocessing and the role of asphaltenes on it. The final chapters describe the hydrocracking and...

Keiji Maruoka

Asymmetric phase transfer catalysis is an emerging topic in the field of organocatalysis and more fascinating asymmetric reactions by organocatalysis are definitely expected in the near future. In contrast to ordinary metal–catalyzed reactions, phase transfer catalysis has several advantages, including its water–tolerable properties with operational simplicity by using environmentally–benign catalysts, and the easy separation of products due to its biphasic nature. Edited by the leading expert on the topic, this timely book provides valuable information not available elsewhere, with top contributors sharing the latest developments in this exciting field. Alongside the theoretical aspects, they cover laboratory protocols as well as applications of the process chemistry and chiral technology in industry. A must for every synthetic chemist in academia and industry.

Bernhard Welz

The thoroughly revised new edition of this best–seller, presents the wide use of AAS in numerous fields of application. The comparison between the different AAS techniques enables the reader to find the best solution for his analytical problem.

Gil Alterovitz

In the last decade DNA sequencing costs have decreased over a magnitude, largely because increasing throughput by incremental advances in tools, technologies and process improvements. Further cost reductions in this and in related proteomics technologies are expected as a result of the development of new high–throughput techniques and the computational machinery needed to analyze data generated. Automation in Proteomics & Genomics: An Engineering Case–Based Approach describes the automation technology currently in the areas of analysis, design, and integration, as well as providing basic biology concepts behind proteomics and genomics. The book also discusses the current technological limitations that can be viewed as an emerging market rather than a research bottleneck. Topics Covered include: molecular biology fundamentals: from ?blueprint? (DNA) to ?task list? (RNA) to molecular machine? (protein); proteomics methods and technologies; modelling protein...

Roger E. Haycock, John E. Hillier

The automotive lubricants arena has undergone significant changes since the first edition of this book was published in 1996. Environmental concerns have dominated both newspaper headlines and industry board rooms in recent years, with particular attention being given to the improvement of air quality. Reduced emissions are directly related to changes in lubricant specifications and quality, and the second edition of the Automotive Lubricants Reference Book reflects the urgency of these matters by including updated and expanded detail. This second edition also considers the recent phenomenon of increased consolidation within the oil and petroleum additive arenas, which has resulted in fewer people for research, development, and implementation, along with fewer competing companies. Of significant importance is the consideration that a more consolidated oil industry -- in need of greater and longer-term returns on investments -- may be less apt to respond to automobile...

Karen C. Timberlake

Basic Chemistry gives readers the problem-solving tools and techniques they need to succeed in future chemistry courses and in the work force. In the clear, approachable writing style characteristic of her texts, Karen Timberlake continues to make chemistry relevant and engaging. Her unique “Guide to Problem-Solving” strategy provides a visual, step-by-step plan that helps students solve a wide variety of problems. Sample and practice problems throughout each chapter allow students of various levels and learning styles to practice and master quantitative skills.Real-world applications cover modern, interesting topics in helping students connect chemical principles to events in their world, while interviews with engineers, doctors, veterinarians, and biochemists show students the importance of chemistry in future careers. Along with a host of in-text enhancements, the Third Edition can now be packaged with MasteringChemistry® — the most advanced chemistry homework and tutorial system...